Clinical experience with CB 1348 (NN-DI(2-chloroethyl,-p-aminophenylbutyric acid) in the treatment of chronic lymphatic leukaemia
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چکیده
منابع مشابه
Clinical trials of p-(di-2-chloroethylamino)-phenylbutyric acid (CB 1348) in malignant lymphoma.
Everett, Roberts, and Ross (1953) synthesized a series of water-soluble aromatic nitrogen mustards, one of which, p-(di-2-chloroethylamino)-phenylbutyric acid (CB 1348), was found to be a powerful inhibitor of the transplanted Walker rat tumour 256 (Haddow, 1952) and was submitted for clinical trial. Ninety-three patients suffering from advanced carcinoma and from lymphomas have been treated wi...
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A 75 year old woman with a 13 year history of classical chronic lymphatic leukaemia (CLL) developed hypercalcaemia. Unlike previous reports, this was not associated with blastic transformation, hyperparathyroidism or features of multiple myeloma, but was due to classical CLL per se.
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Haptoglobin phenotypes have been determined in 30 chronic lymphatic leukaemia patients and concentrations determined in 21 of these. The number ofHpl phenotypes is slightly raised but not significantly so compared with a control population and is the same as that in first-degree relatives. Haptoglobin concentrations show higher concentrations in Hpl than Hp2, as has previously been reported. It...
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These results are similar to those obtained by Schluederberg (1965), who found consistent twofold to fourfold reductions in antibody titre after treatment with 2ME in serum obtained at 12-day to 21-day intervals after measles vaccination and natural infection with mumps virus, but no reduction in those obtained two months or more after infection. Lindquist et al. (1965), employing neutralizatio...
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The first clinical trial in malignant lynsphoma appeared in 1955.2 The authors found the drug to be definitely useful in follicular lymphoma and lymphocytic leukemia, and to some extent in Hodgkin’s disease. They concluded that it deserved further trial. This opinion was recently concurred in by a group of workers in this country3 who treated 24 patients. Our work with CB 1348 involved 31 patie...
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ژورنال
عنوان ژورنال: Acta Radiologica
سال: 1957
ISSN: 0001-6926
DOI: 10.3109/00016925709170889